I'm going to tap out what may be one of my verbose responses, but will give you some history, and may shed some light on why this oft discussed topic gets a lot of heat, but little light.
Early on in the Valk production, 2 outfits made the wheels, LaMonster and Airlake. The 4° wheel was for the Goldwing, and the 6° wheel for the Valk. Then along came the Interstate. It had 2° more initial advance. Folks were putting the 6° wheel on the I/S with mixed success. Some would love them, and others would complain that there was too much pinging and preignition noise. In order to make the most customers happy, the answer was to use the 4° wheel on the I/S.
I had an I/S, and many more like me rode either an I/S or a STD/Tourer with an I/S ICM and used a 6° wheel with no problem at all, and lots of power, and a small bit of mileage increase.
With many chiming in, the outcome of all the responses was that those who ran their Valks at low RPM and rolled the throttle hard from 2500 or less would have preignition or pinging.
Those that ran at 3000 or above, or downshifted to accelerate hard, had no problems at all. This group also found no need to use anything more than regular gas.
Many are of the opinion that the ECT mod is the same or better than the wheel mod. I disagree. The ECT mod is only active to about 3600 RPM, where it reverts to normal timing. I want the advance up higher, and can only get that with a wheel.
What it comes down to is if you lug your Valk, the 6° wheel is probably not for you. If you spank that bad girl and make her howl, you will like the 6° wheel and get the most performance from the mod.
It has also been said that you lose some top end with the 6° wheel. That may be true. My outlook on it is that I use the acceleration a lot, and use top speed almost never. Mine with a 6° wheel would do 125 MPH on a GPS. Fast enough for a fat girl.
Hope that clears some of the variables in the decision-making process!

I just looked and have a 6° LaMonster wheel. I'll sell it for the same price the E-Bay wheel goes for.
What is the difference from the standard trigger wheel? Is it really neccesary to go to premium fuel with the 4° wheel.