I avoid Louisville anytime I possibly can. The biggest problem with Louisville is crossing the bridge southbound. All of the idiots in the right 2 lanes are funneling down to the right lane for the ramp to I-64 and I-71. If you are going straight through on I-65, ride slowly, alertly, and stay in left lane. If you are needing to go east on I-64, I would suggest looking at an alternative route during rush hour. I have crossed at Madison several times and it is a nice ride. You can get off at exit 50, go over to highway 7 and down or take exit 29 and use highway 56 to go to Madison. Since you are going home, your best bet is to go straight through on 65. You could always stop here at Seymour for a meal with me and wait for rush hour to lighten up a bit.
