I have recently noticed a clunk in the drive line when I throttle up or down (change from acceleration to deceleration) in any given gear. I dont remember hearing this before, but do not think this is normal.

Sound seems to be coming from area of u-joint. Spline lube has always been done at normal intervals, I put new tire on recently and splines were just fine, have always tightened the last 4 bolts on final drive AFTER wheel installation, per instructions. I have 52K on the clock- have pulled trailers.
There does not seem to be any vibration or unusual noises. . . . but I suspect the u-joint. Have ordered u-joint and boot- am I on the right track?
Could there be other possible causes for the clunk?
Thx