Most folks would consider me an internet power user. With that said, I use plain ole google.com as my start page.
Any links that I need, or frequently use, are saved on my browser toolbar. I have a dozen or so listed there with shortened names to save space. All bookmarks are saved to
http://delicious.com/ via their Firefox extension which allows me to sync my bookmarks across all the computers I use(4). (I have over 700 bookmarks/favorites saved there) I save anything I might want to refer to later and i can tag them with keywords for easy retrieval.
Why do I use google as my start page? Because I use google more than anything else and it loads lightning fast. A quick click on the Home icon in Firefox, and I'm back at google.com and ready to do a search.
If you want a truely customizable, unique, feature rich homepage you should try
http://www.netvibes.com . You can add widgets for just about everything. Weather, news, your email, links, rss feeds, stocks, facebook, blogs...the list is endless. Re-aranging things is as simple as dragging items around the page.
-Scott