Probably best to avoid 465 during any time during rush hour. If you have to go that way, expect possible long delays in traffic and the crazies.
I would suggest a western route if possible. 41 to Vincennes and then 150 across to French Lick would be a decent ride. Also 231 down to 150 is a nice ride. It would possibly be a shorter ride for you if you went a western route vs around Indy. There is no FAST, direct route to French Lick. Let us know if you hit the casino.

If you go 231, wave as you go thru Crawfordsville.
