Trust that you know that timing marks indicate set point for one or the other of the two cylinders indicated as the marks indicate the "running mates", one of the two will be at TDC exhaust and the other will be at TDC compression.
The one that is TDC exhaust the valves will be "on the rock' or in overlap position as they are in transition from exhaust to intake, and so both valves will be on the cam lobes and off of the base circle of the cam. Both valves will be slightly open as the exhaust valve is still in the process of closing and the intake valve is starting to open.
The one that is TDC compression will have both valves on "base circle" of their respective cam lobes. The piston has come up and compressed the air\fuel charge the plug has just fired (BTDC) and the piston is transitioning to going down on the power stroke.
Running mates can be determined by looking at the firing order (typical inline 6 cylinder is 1,5,3,6,2,4) then take the cylinders in the first half of the firing order (1,5,3, in this case) and write them down over the second half of the firing order - 1 goes over 6, 5 goes over 2, 3 goes over 4. This shows you the "running mates" - 1&6, 5&2, 3&4,. This will work for every configuration that has equidistant crankshaft throws in any configuration - I have used it up to V-16's
Once you have determined the running mates it is a logical process to follow through and set the valves.
- line up timing mark for 1&6,
- check valves for both cylinders,
- one of the two both valves will be tight whereas the valves for the running mate both valves will be on base circle.
- If you watch the valves as you turn the engine in the proper direction of rotation as you approach the timing mark you will see the exhaust valve closing and the intake valve opening.
This cylinder is "on the rock" - adjust the valves on it's running mate as they are both on base circle.
In the case given if 1 is "on the rock" set the valves for 6, then turn to next timing mark (turn crank 120° for 6 cylinder) and cylinder 5 should be "on the rock" so set the valves for #2 etc. etc. You can usually determine which valve is which (intake or exhaust) by looking at the head casting and valve position relative to the intake and exhaust manifolds to see which one best lines up.
If you look at the firing order for the F6 you will see that it go from front to back then the middle and crosses banks through the process. so the front cylinders are mates, the back cylinders are mates and the middle cylinders are mates.