That is the preferred route. Surface is usually in good repair and traffic flows nicely In mostly. You will encounter some congestion at spots, but can usually manage to keep rolling.
250 is very scenic, look for the Amish. It gets very twisty as you approach the Ohio River, but traffic sometimes gets hairy just before Wheeling.
Tip:
Take one of the side roads south off of 250 to avoid Wheeling, if traffic is weird coming down the mountain. There are a couple that will take you to 220.
I’ve gone this way dozens of times.
Enjoy!