There are options to avoid the interstates. From Sedona to Parker to 29 Palms to Victorville to Ventura. Will take a little longer but much more enjoyable on a bike in my opinion.

Have you done this route ??
There's no 4 lanes , so passing is a problem , and head on traffic , too.
I like the idea , though , many less trucks
However , interstate means all traffic going in the same direction ( okay , not all , but you know what I mean )